Vitamin Injections · San Diego
Vitamin Injections in San Diego: B12, Vitamin D, NAD+ and more
Intramuscular (IM) Vitamin Injections deliver micronutrients straight into muscle tissue, where they are absorbed into the bloodstream without depending on stomach acid, intrinsic factor or a healthy gut lining. For biohackers, busy professionals and anyone whose labs show low B12 or vitamin D, a 15-minute shot is one of the most efficient ways to close a nutrient gap.
At Saffron & Sage, every injection is reviewed by a licensed prescriber and given by our Registered Nurses or Naturopathic Doctors. Start with a Holistic Health Check-In, then get your shots in our clinic or at home.
- Starting at $25 per injection
- 15-minute visits, or add to your IV
- Prescriber-reviewed, given by RNs and NDs
- Start with a Holistic Health Check-In
- HSA, FSA and LSA welcome, always gratuity-free
- Visit
- 15 minutes
- Cost
- From $25 per injection
- Practitioners
- Registered Nurses and Naturopathic Doctors
- Payment
- HSA, FSA and LSA welcome
- Where
- 2555 State St, San Diego
New patients
How to start Vitamin Injections
Vitamin Injections are paid per injection, starting at $25, and do not use membership credits. To get access, every new patient starts with a Holistic Health Check-In, where a Doctor reviews your health history and labs and builds your injection plan. After that, get your shots in our clinic, or take them home after a short Injectables Onboarding.
1 medical credit
Your Holistic Health Check-In
- A health review with a Naturopathic Doctor
- Labs reviewed to see what you are actually low in
- A personalized injection protocol
Medical credit + consultation
Holistic Health Check-In + consultation
- Your Holistic Health Check-In
- A full consultation and health history, a $300 value, included
- Lab review if you bring recent results
New patients. Through November 26, 2026. Book online and pay at checkout. HSA, FSA and LSA welcome. We are direct pay and do not bill insurance; superbills are available on request.
Two ways to get your injections
In our clinic: after your Check-In, book a 15-minute injection visit or add a shot to your IV Therapy. No onboarding needed.
At home: after your Check-In, our team schedules your Injectables Onboarding, where your nurse shows you how to give your injection safely. Then you can take your injections home.
Not sure Vitamin Injections is right for you?
Talk it through on a free discovery call first. Book a discovery call
Why patients book
Why patients book Vitamin Injections
These are the reasons we hear most from people across San Diego, from Little Italy and Downtown to Mission Hills and North Park. Most start with labs, then use injections to correct what the numbers show.
Low energy and fatigue
Tired despite sleep, often with low or low-normal B12, ferritin or vitamin D on labs.
Brain fog and focus
B12 and B-complex vitamins are cofactors for neurotransmitter synthesis and myelin.
Poor absorption
Low stomach acid, PPIs, metformin, IBS or a plant-based diet all limit oral B12 absorption.
Immune resilience
Extra support through cold and flu season, travel and high-stress stretches.
Travel and jet lag
Before or after a long flight, to support immunity, hydration and recovery.
Pair with an IV drip →Metabolic and weight goals
Lipotropic and B-vitamin support alongside nutrition, training and labs.
Sleep and stress
Nutrients involved in GABA and melatonin pathways for a nervous system that won’t switch off.
Longevity and performance
NAD+ for cellular energy and healthy aging, as part of a lab-guided protocol.
The basics
What are Vitamin Injections, and how do they work?
Vitamin Injections are intramuscular shots, usually into the deltoid (upper arm) or the gluteal muscle. Muscle is highly vascular, so the nutrient enters circulation steadily over hours, bypassing the digestive tract entirely. Oral absorption of B12, for example, depends on stomach acid and intrinsic factor and saturates at about 1.5 mcg per meal; an IM dose does not.
B12 is a cofactor for methionine synthase and methylmalonyl-CoA mutase, two enzymes behind methylation, homocysteine clearance, myelin maintenance and red blood cell formation. Vitamin D works more like a hormone: the vitamin D receptor is found in immune cells, muscle and bone, and many people in San Diego still test insufficient because of sunscreen and indoor work.
NAD+ (nicotinamide adenine dinucleotide) carries electrons in mitochondrial energy production and is the fuel for sirtuins and PARP enzymes involved in DNA repair. Tissue NAD+ declines with age, which is why it has become a cornerstone of longevity protocols.
Vitamin Injections vs IV Therapy
An injection delivers a concentrated dose of one or a few nutrients in seconds. An IV drip delivers a larger volume with fluids and electrolytes over about an hour. Many patients use IV Therapy monthly and injections weekly in between, guided by Diagnostic Testing and Nutritional Therapy.
What it feels like
Quick, simple and over in minutes
The injection itself takes a few seconds. Most people feel a small pinch in the upper arm and some notice mild soreness at the site for a day. B12 can tint urine slightly pink-red for a day, which is harmless.
With B12, some people feel an energy lift within hours; with vitamin D and other nutrients, the effect builds over weeks as levels rise. Your Registered Nurse will tell you what to expect and how often to come back.
Tell us before your injection if you:
- Are pregnant or breastfeeding
- Take blood thinners or have a bleeding disorder
- Have allergies to vitamins, cobalt or preservatives
- Have kidney disease or Leber’s disease
Your visit
Your Vitamin Injections appointment, step by step
Book your Holistic Health Check-In
A Doctor reviews your health history and labs and recommends your injections. It uses 1 medical credit for members.
Choose clinic or home
In-clinic shots need no onboarding. For at-home injections, our team schedules your Injectables Onboarding.
Your injection
Your Registered Nurse or Naturopathic Doctor gives your injection in a 15-minute visit, or you give it at home as you were shown.
Your protocol
We recommend a rhythm, such as weekly B12 for a month or a seasonal immune series, and when to re-test your labs.
Choose your injection
Our Vitamin Injections
Each injection is a quick IM shot, starting at $25 and paid per injection, not with membership credits. Your nurse walks you through each formula’s ingredients before your injection.
Per injection
B12
The active cofactor for methylation, homocysteine clearance, myelin and red blood cell formation. Bypasses intrinsic-factor absorption, so it works when oral B12 does not. Often weekly for 4 weeks, then monthly.
Per injection
Vitamin D
A hormone-like vitamin that regulates calcium absorption, muscle function and innate immunity through the vitamin D receptor. Dosed against your 25-OH vitamin D level.
Per injection
Energy
A B-complex formula: B1, B2, B3, B5 and B6 are cofactors in glycolysis, the Krebs cycle and the electron transport chain where mitochondria make ATP.
Per injection
Immunity
Nutrients involved in innate and adaptive immune defence, such as vitamin C, zinc and B vitamins, for cold and flu season, travel and high-stress weeks.
Per injection
Metabolism
A lipotropic-style formula that supports fat metabolism in the liver and energy production, used alongside a nutrition and training plan.
Per injection
Beauty
Nutrients such as biotin and B vitamins that support keratin production for hair and nails and collagen-supporting pathways for skin.
Per injection
Antioxidant
An antioxidant formula, chosen with your Doctor after a consultation.
Per injection
Sleep
A calming formula built around nutrients such as magnesium and B6, cofactors in GABA, serotonin and melatonin synthesis.
Per injection
NAD+
The coenzyme behind mitochondrial energy production and sirtuin-driven DNA repair, which declines with age. Usually a series over a few weeks; a brief warm flush is common.
NAD+ as an IV drip →Per injection
Travel Immunity
A pre- and post-flight protocol to support immunity, hydration and recovery before, during and after a trip.
Prescription
Weight management
Prescription support for body composition goals, with glucose and weight monitoring and labs every 90 days. GLP-1s are peptides. See Peptide Therapy
Free call
Build your protocol
Not sure which injections fit your labs and goals? Talk it through on a free discovery call first.
Book a free discovery call →Go further
Peptide injections and IV drips
Ready for more than a vitamin shot? Two places patients go next.
Physician-led
Peptide injections
Prescription peptide protocols for recovery, body composition, sleep and healthy aging, started only after a medical assessment and labs, with injection teaching and follow-up.
Explore Peptide Therapy →100% absorbed
IV drips
NAD+, Myers’, immunity, hydration and Doctor-directed drips delivered straight into the bloodstream with fluids and electrolytes, in our IV lounge.
Explore IV Therapy →Your practitioners
Meet our injection team
Vitamin Injections are reviewed by a licensed prescriber and given by our Registered Nurses and Naturopathic Doctors, overseen by our Medical Director.
ND, MHSN
Dr. Alexander Aponte-Davila
Naturopathic Doctor and Nutritionist. Labs, gut and hormone health, nutrition, peptides and IV care.
Read bio →
ND
Dr. Nazanin Ghetmiri
Naturopathic Doctor. Gut, endocrine and women’s health, hormones, Microneedling and IV care.
Read bio →
RN
Karen Catalano
Registered Nurse. Vitamin Injections and IV care, from intake to aftercare.
RN
Karissa Agosto
Registered Nurse. Vitamin Injections and IV care, from intake to aftercare.
Book online
Book your Vitamin Injections
New patients start with a Holistic Health Check-In. After that, choose your injection, pick your practitioner and a time, and pay per injection at checkout.
New to Saffron & Sage? Start with your Holistic Health Check-In for $250, normally $300.
Book now
Location
Vitamin Injections near Little Italy, San Diego
Saffron & Sage is in Mission Hills, just north of Little Italy, a short drive from Downtown, Bankers Hill, Point Loma and North Park. Many patients come in before or after work.
Hours: Monday and Thursday 8am to 2pm; Tuesday, Wednesday and Friday 8am to 8pm.
Questions
Vitamin Injections FAQs
How much does Vitamin Injections cost in San Diego at Saffron & Sage?
At Saffron & Sage, Vitamin Injections start at $25 and are paid per injection, not with membership credits. Every new patient starts with a Holistic Health Check-In ($250, normally $300). After that, get your shots in a 15-minute visit, add one to your IV Therapy, or take them home after an Injectables Onboarding. HSA, FSA and LSA dollars are welcome.
Which Vitamin Injection should I choose?
It depends on your goals and labs. B12 and Vitamin D are the most common starting points. Ask our team when you book, or have a Naturopathic Doctor review your labs first.
Are B12 injections better than B12 pills?
For people who absorb poorly, yes. Oral B12 needs stomach acid and intrinsic factor, and absorption is limited per dose. IM B12 bypasses the gut, which is why it is standard care for B12 deficiency and pernicious anemia.
How often should I get a B12 injection?
Many people start with weekly injections for the first month, then maintenance every few weeks. Your practitioner will recommend a rhythm based on your symptoms and labs.
How long do the effects last?
It depends on the nutrient and your levels. B12 is stored in the liver, so a correction can last weeks; water-soluble blends are used more often. Re-testing shows whether your levels are holding.
Vitamin Injections or IV Therapy: which is better?
They do different jobs. An injection is a quick, concentrated dose of a few nutrients. An IV drip delivers more nutrients plus fluids over about an hour. Many patients combine the two.
Do Vitamin Injections hurt?
Most people feel a small pinch in the upper arm. Some notice mild soreness at the site for a day.
What is an NAD+ injection?
NAD+ is a coenzyme your cells use to make energy and repair DNA, and levels fall with age. NAD+ injections are usually given as a series over a few weeks. A brief warm or flushed feeling is common and passes quickly.
Can I add an injection to my IV?
Yes. Add any injection when you book your IV Therapy, or ask your nurse on the day.
Who gives the injections?
Our Registered Nurses and Naturopathic Doctors give injections in the clinic, after your Holistic Health Check-In. At-home patients give their own after an Injectables Onboarding.
Do I need labs first?
Not for most Vitamin Injections. Labs are required for prescription protocols such as weight management, peptides and TRT, and are a good idea if you want to know whether you are actually low.
How do I book Vitamin Injections?
Start by booking your Holistic Health Check-In. After that, book 15-minute injection visits online or add a shot to your IV. If you would like to inject at home, our team schedules your Injectables Onboarding. You can also call (619) 933-2340.
Is Vitamin Injections covered by insurance or HSA?
We accept HSA, FSA, HRA and LSA funds. Your plan administrator decides which services are eligible, so please check with your plan. We are direct pay and do not bill insurance; superbills are available on request.
Do Vitamin Injections use membership credits?
No. Vitamin Injections are paid per injection, starting at $25, whether you are a member or not. Your Holistic Health Check-In uses 1 medical credit for members.
Can I do my injections at home?
Yes. After your Holistic Health Check-In, our team schedules your Injectables Onboarding, where your nurse shows you how to give your injection safely. Injections given in our clinic do not need onboarding.
Where are you located?
2555 State Street, Suite 101, San Diego, CA 92101, just north of Little Italy. The entrance is on West Maple Street. Call (619) 933-2340.
Free guide
Use the health money you already set aside.
Our free guide to using HSA and FSA dollars for your care. The current limits, the rules that changed for 2026, and the traps that quietly cost people money. Not tax advice.
- HSA, FSA and HRA: how they differ
- The rules that changed for 2026
- Five traps that quietly cost people money
Keep reading
More on Vitamin Injections
Ready when you are
Start with your Holistic Health Check-In
Book your Holistic Health Check-In for $250, or add a full consultation for $300, normally $600. Not sure yet? Our team will listen, explain your options and help you pick the right appointment and practitioner.
All medical services are provided by Kasawa Medical APC dba Saffron & Sage MD. Vitamin Injections are given after a Holistic Health Check-In with a Doctor. They are not a substitute for a balanced diet or medical care and are not intended to diagnose, treat, cure or prevent any disease. Please tell us about pregnancy, allergies, bleeding disorders and all medications. If you have a severe reaction or trouble breathing, call 911.